Pauson Khand reaction

Cobalt catalysed Pauson Khand reaction (PKr)


Recently, we have studied the role of electronic regioguidance in the case of alkynes substituted either a) aromatic or b) aliphatic symmetric substitution.


Related publications:

E. Fager-Jokela, M. Muuronen, H. Khaizourane, A. Vázquez-Romero, X. Verdaguer, A. Riera, J. Helaja: Regioselectivity of Intermolecular Pauson–Khand Reaction of Aliphatic Alkynes: Experimental and Theoretical Study of the Effect of Alkyne Polarization J. Org. Chem. 2014, 79, 10999–11010.

E. Fager-Jokela, M. Muuronen, M. Patzschke, J. Helaja: Electronic Regioselectivity of Diarylalkynes in Cobalt Mediated Pauson-Khand Reaction: An Experimental and Computational study with para- and meta-Substituted Diarylalkynes and Norbornene J. Org. Chem. 2012, 77, 9134-9147.